methotrexate solution  (MedChemExpress)

Journal: Scientific Reports

Article Title: Immunoprognostic model of lung adenocarcinoma and screening of sensitive drugs

doi: 10.1038/s41598-022-11052-8

Figure Lengend Snippet: CMap database drug screening.

Article Snippet: We further prepared a solution of resveratrol (Lot#:C12594500, Macklin, China), methotrexate (Lot#: C12150088, Macklin, China), phenoxybenzamine (Lot#: C11947938, Macklin, China), and thiostrepton.

Techniques:

Journal: Scientific Reports

Article Title: Immunoprognostic model of lung adenocarcinoma and screening of sensitive drugs

doi: 10.1038/s41598-022-11052-8

Figure Lengend Snippet: CMap database drug screening and cytological activity validation. ( a ) Optimal compounds and their structures screened from the CMap database. ( b ) DMSO solvent toxicity assay. ( c ) Inhibition rate of the resveratrol compound on A549 cells. ( d ) Inhibition rate of the methotrexate compound on A549 cells. ( e ) Inhibition rate of the phenoxybenzamine compound on A549 cells.

Article Snippet: We further prepared a solution of resveratrol (Lot#:C12594500, Macklin, China), methotrexate (Lot#: C12150088, Macklin, China), phenoxybenzamine (Lot#: C11947938, Macklin, China), and thiostrepton.

Techniques: Drug discovery, Activity Assay, Biomarker Discovery, Solvent, Inhibition

Journal: Cancers

Article Title: Synergistic Anti-Tumor Effect of Simvastatin Combined to Chemotherapy in Osteosarcoma

doi: 10.3390/cancers13225869

Figure Lengend Snippet: IC 50 values of drugs in the murine K7M2 cell line, as assessed by the MTT test after 24 h of exposure. n.d. not determined.

Article Snippet: Methotrexate (CAS number RN 59-05-2) was purchased as a 55 mM injectable solution from Mylan (Saint Priest, France).

Techniques: